Publications

​2019
  • de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL. Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nature Communications. 2019 Aug 1;10(1):3468. doi: 10.1038/s41467-019-11429-w.
  • Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Targeted Degradation of Aberrant Tau in Frontotemporal Dementia Patient-Derived Neuronal Cell Models. Elife. 2019 Mar 25;8. pii: e45457. DOI:10.7554/eLife.45457.
  • Jiang B, Wang ES, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angewandte Chemie International Edition. 2019 Feb 25. [Epub ahead of print]  DOI:10.1002/anie.201901336.
  • Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chemical Biology. 2019 Feb 21;26(2):300-306.e9. Epub 2018 Dec 27. DOI:10.1016/j.chembiol.2018.11.006.
  • Dobrovolsky D, Wang ES, Morrow S, Leahy C, Faust T, Nowak RP, Donovan KA, Yang G, Li Z, Fischer ES, Treon SP, Weinstock DM, Gray NS. Bruton Tyrosine Kinase Degradation as a Therapeutic Strategy for Cancer. Blood. 2019 Feb 28;133(9):952-961. Epub 2018 Dec 13. DOI:10.1182/blood-2018-07-862953.
2018
  • Donovan KA, An J, Nowak RP, Yuan JC, Fink EC, Berry BC, Ebert BL, Fischer ES. Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Elife 2018 Aug 1;7. pii: e38430. DOI: 10.7554/eLife.38430.
  • Sievers QL, Gasser JA, Cowley GS, Fischer ES, Ebert BL. Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. Blood. 2018 Sep 20;132(12):1293-1303. Epub 2018 Jul 24. DOI: 10.1182/blood-2018-01-821769.
  • Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 Jul 12;174(2):300-311.e11. DOI: 10.1016/j.cell.2018.06.026
  • Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nature Chemical Biology Nat Chem Biol. 2018 Jul;14(7):706-714. Epub 2018 Jun 11. DOI:10.1038/s41589-018-0055-y
  • Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). Journal of Medicinal Chemistry. 2018 May 10;61(9):4249-4255. Epub 2018 Apr 24. DOI: 10.1021/acs.jmedchem.7b01655. 

2017
  • Terai H, Kitajima S, Potter DS, Matsui Y, Quiceno LG, Chen T, Kim TJ, Rusan M, Thai TC, Piccioni F, Donovan KA, Kwiatkowski N, Hinohara K, Wei G, Gray NS, Fischer ES, Wong KK, Shimamura T, Letai A, Hammerman PS, Barbie DA. ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors. Cancer Research 2018 Feb 15;78(4):1044-1057. CAN-17-1904. Epub 2017 Dec 19. DOI:10.1158/0008-5472.
  • Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nature Chemical Biology. 2018 Feb;14(2):163-170. Epub 2017 Dec 18. DOI:10.1038/nchembio.2538. 
  • Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J, Shi K, Choi HG, Griffin JD, Li Y, Treon SP, Fischer ES, Bradner JE, Tan L, Gray NS. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chemical Biology. 2018 Jan 18;25(1):88-99. Epub 2017 Nov 9. DOI:10.1016/j.chembiol.2017.10.005. 
  • Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS. Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chemical Biology. 2017; 24(8):1005-1016.e3. Epub 2017 Aug 3. DOI:10.1016/j.chembiol.2017.06.017.
  • An J, Ponthier CM, Sack R, Seebacher J, Stadler MB, Donovan KA, Fischer ES. pSILAC mass spectrometry reveals ZFP91 as IMiD dependent substrate of the CRL4CRBN ubiquitin ligase. Nature Communications 2017 May 22;8:15398. DOI:10.1038/ncomms15398.
2016
  • Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH. Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature 2016 Mar 31;531(7596):598-603. DOI:10.1038/nature17416.
  • Fischer, E.S.‡, Park, E., Eck, M.J.‡, Thomä, N.H‡. SPLINTS: small-molecule protein ligand interface stabilizers. Current Opinion in Structural Biology 2016; 37:115-122. DOI:10.1016/j.sbi.2016.01.004.
  • Petzold, G., Fischer, E.S., Thomä, N.H. Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 2016 Apr 7; 532(7597):127-130 DOI:10.1038/nature16979.
– 2015
  • Matsumoto, S., Fischer, E.S., Yasuda, T., Dohmae, N., Iwai, S. Mori, T., Nishi, R., Yoshino, K., Sakai, W., Hanaoka, F., Thoma, N.H., Sugasawa, K. Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein. Nucleic Acids Research 2015 Feb 18; 43(3): 1700-13. PMCID: PMC4330392. DOI:10.1093/nar/gkv038.
  • Lingaraju, G.M.*, Bunker, R.D.*, Cavadini, S., Hess, D., Hassiepen, U., Renatus, M., Fischer, E.S., Thomä, N.H. Crystal structure of the human COP9 Signalosome. Nature 2014; 512(7513): 161-165. DOI:10.1038/nature13566.
  • Fischer, E.S., Böhm, K., Lydeard, J.R., Yang, H., Stadler, M.B., Cavadini, S., Nagel, J., Acker, V., Tichkule, R., Forrester, W.C., Schirle, M., Hassiepen, U., Ottl, J., Hild, M., Beckwidth, R.E.J., Harper, J.W., Jenkins, J.L., Thomä, N.H. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.  Nature 2014; 512(7512): 49-53. PMCID: PMC4423819. DOI:10.1038/nature13527.
  • Fischer, E.S.*, Scrima, A.*, Boehm, K., Matsumoto, S., Lingaraju, G.M., Faty, M., Yasuda, T., Cavadini, S., Wakasugi, M., Hanaoka, F., Iwai, S., Gut, H., Sugasawa, K., Thomä, N.H. The molecular basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting and Activation. Cell 2011; 147(5): 1024-1039. DOI:10.1016/j.cell.2011.10.035.
  • Scrima, A., Fischer, E.S., Lingaraju, G.M., Böhm, K., Cavadini, S., Thomä, N.H. Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!. FEBS Letters 2011; 585(18): 2818-25. DOI:10.1016/j.febslet.2011.04.064

* equal contribution
‡ shared corresponding authors
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